Doxorubicin or Adriamycin, is one of the most widely used chemotherapeutic drug for
treating a myriad of cancers. It induces cell death through multiple intracellular targets …

Chemotherapeutic antibiotic doxorubicin belongs to the anthracycline class, slaughters not
only the cancer cells but also non-cancerous cells even in the non-targeted organs thereby …

Many studies have shown that toxicities of anticancer drugs and their adverse effects are
related to their chemical structure and high molecular weight that may result in a number of …

The anthracycline doxorubicin (DOX) is widely used in chemotherapy due to its efficacy in
fighting a wide range of cancers such as carcinomas, sarcomas and hematological cancers …

The present review discusses recent work on melatonin-mediated circadian regulation, the
metabolic and molecular signaling mechanisms that are involved in human breast cancer …

Abstract Objectives Doxorubicin (Dox) belongs to the anthracycline drug classification and is
a widely administered chemotherapeutic. However, Dox use in therapy is limited by its …

Many clinical studies involving anti-tumor agents neglect to consider how these agents are
metabolized within the host and whether the creation of specific metabolites alters drug …

Doxorubicin is an effective anti-neoplastic agent; the reported toxicities of DOX limit its use.
Luteolin is a polyphenolic phytochemical that exhibits beneficial biological effects via …

Most clinically used drugs are metabolized in the body via oxidation, reduction, or hydrolysis
reactions, which are considered phase I reactions. Cytochrome P450 (P450) enzymes …

The emergence of silymarin (SMN) as a natural remedy for liver diseases, coupled with its
entry into NIH clinical trial, signifies its hepatoprotective potential. SMN is noted for its ability …