The LDL receptor-related protein (originally called LRP, but now referred to as LRP1) is a
large endocytic receptor that is widely expressed in several tissues. LRP1 is a member of …

▪ Abstract Ubiquitin regulates protein transport between membrane compartments by serving
as a sorting signal on protein cargo and by controlling the activity of trafficking machinery …

A RING finger-containing protein (AO7) that binds ubiquitin-conjugating enzymes (E2s) and
is a substrate for E2-dependent ubiquitination was identified. Mutations of cation …

Receptor desensitization is accomplished by accelerated endocytosis and degradation of
ligand–receptor complexes. An in vitro reconstituted system indicates that Cbl adaptor …

Ubiquitin-protein ligases (E3s) regulate diverse cellular processes by mediating protein
ubiquitination. The c-Cbl proto-oncogene is a RING family E3 that recognizes activated …

Ligand-induced activation of transmembrane receptors activates intracellular signaling
cascades that control vital cellular processes, such as cell proliferation, differentiation …

Critical cellular processes are regulated, in part, by maintaining the appropriate intracellular
levels of proteins. Whereas de novo protein synthesis is a comparatively slow process …

Ubiquitination of receptor protein-tyrosine kinases (RPTKs) terminates signaling by marking
active receptors for degradation. c-Cbl, an adapter protein for RPTKs, positively regulates …

The ubiquitin‐proteasome pathway has emerged as a central player in the regulation of
several diverse cellular processes. Here, we describe the important components of this …

Responses to extracellular stimuli are often transduced from cell-surface receptors to protein
tyrosine kinases which, when activated, initiate the formation of protein complexes that …