[HTML][HTML] Non-physiological shear stress-induced blood damage in ventricular assist device

Z Chen, A Sun, H Wang, Y Fan, X Deng - Medicine in Novel Technology …, 2019 - Elsevier
Ventricular assist devices (VADs) have been used for treating the end-stage heart failure
(HF) patients in the past few decades, which had improved survival rates. In parallel, clinical …

Mechanical shear stress and leukocyte phenotype and function: Implications for ventricular assist device development and use

G Radley, S Ali, IL Pieper… - … International Journal of …, 2019 - journals.sagepub.com
Heart failure remains a disease of ever increasing prevalence in the modern world. Patients
with end-stage heart failure are being referred increasingly for mechanical circulatory …

Shear stress‐induced total blood trauma in multiple species

CHH Chan, IL Pieper, CR Robinson… - Artificial …, 2017 - Wiley Online Library
The common complications in heart failure patients with implanted ventricular assist devices
(VADs) include hemolysis, thrombosis, and bleeding. These are linked to shear stress …

The C entri M ag centrifugal blood pump as a benchmark for in vitro testing of hemocompatibility in implantable ventricular assist devices

CHH Chan, IL Pieper, R Hambly, G Radley… - Artificial …, 2015 - Wiley Online Library
Implantable ventricular assist devices (VADs) have proven efficient in advanced heart failure
patients as a bridge‐to‐transplant or destination therapy. However, VAD usage often leads …

The Effect of Shear Stress on the Size, Structure, and Function of Human v on W illebrand Factor

CHH Chan, IL Pieper, S Fleming, Y Friedmann… - Artificial …, 2014 - Wiley Online Library
Clinical outcomes from ventricular assist devices (VADs) have improved significantly during
recent decades, but bleeding episodes remain a common complication of long‐term VAD …

Extracorporeal membrane oxygenation-induced hemolysis: An in vitro study to appraise causative factors

CHH Chan, KK Ki, M Zhang, C Asnicar, HJ Cho… - Membranes, 2021 - mdpi.com
In vitro hemolysis testing is commonly used to determine hemocompatibility of
ExtraCorporeal Membrane Oxygenation (ECMO). However, poor reproducibility remains a …

A two-stage rotary blood pump design with potentially lower blood trauma: a computational study

B Thamsen, R Mevert, M Lommel… - … journal of artificial …, 2016 - journals.sagepub.com
Aim In current rotary blood pumps, complications related to blood trauma due to shear
stresses are still frequently observed clinically. Reducing the rotor tip speed might decrease …

[HTML][HTML] Extracellular vesicles: biomarkers and regulators of vascular function during extracorporeal circulation

MJ McVey, WM Kuebler - Oncotarget, 2018 - ncbi.nlm.nih.gov
Extracellular vesicles (EVs) are generated at increased rates from parenchymal and
circulating blood cells during exposure of the circulation to abnormal flow conditions and …

Hemodilution increases the susceptibility of red blood cells to mechanical shear stress during in vitro hemolysis testing

CR Sargent, IL Perkins, V Kanamarlapudi… - ASAIO …, 2021 - journals.lww.com
Abstract The American Society for Testing and Materials (ASTM) F1841 standard for the
assessment of hemolysis in blood pumps recommends using phosphate-buffered saline …

The effect of air exposure on leucocyte and cytokine activation in an in-vitro model of cardiotomy suction

CJ Toomasian, SR Aiello, BL Drumright, TC Major… - …, 2018 - journals.sagepub.com
Introduction: Cardiopulmonary bypass (CPB) is known to cause a systemic inflammatory and
immune response. Objective: An in-vitro model of cardiotomy suction was designed to …