In the big data era, voluminous datasets are routinely acquired, stored and analyzed with the
aim to inform biomedical discoveries and validate hypotheses. No doubt, data volume and …

The angiotensin II (Ang II) type 1 and type 2 receptors (AT1R and AT2R) orchestrate an
array of biological processes that regulate human health. Aberrant function of these …

A multifunctional copolymer–anticancer conjugate chitosan-graft-polyethyleneimine-
candesartan (CPC) containing low molecular weight chitosan (CS) backbone and …

Introduction Hyperhomocysteinemia (HH cy) impairs nitric oxide endothelium‐dependent
vasodilation, consequently leading to atherosclerosis, a risk factor for cardiovascular …

Background Breast cancer is among the deadliest cancers across the world and is
responsible for countless deaths. There is an urgent need for co-delivery systems which can …

The family of adenosine receptors (ARs) is focus of several medicinal chemistry programs
aimed to find new potent and selective drugs. Each receptor subtype has been proposed as …

The drug: membrane interactions for the antihypertensive AT1 antagonist losartan, the
prototype of the sartans class, are studied herein using an integrated approach. The …

Smell and taste are among the basic senses with which we perceive the world around us. In
addition to enabling recognition of chemical moieties that provide social or nutritional clues …

In this article, the conformational properties of olmesartan and its methylated analogue were
charted using a combination of NMR spectroscopy and molecular modeling. For the …

Computer-aided drug discovery (CADD) tools have provided an effective way in the drug
discovery pipeline for expediting of this long process and economizing the cost of research …