Immune checkpoint inhibitor-associated pneumonitis in non-small cell lung cancer: current understanding in characteristics, diagnosis, and management

Q Zhang, L Tang, Y Zhou, W He, W Li - Frontiers in immunology, 2021 - frontiersin.org
Immunotherapy that includes programmed cell death-1 (PD-1), programmed cell death-
ligand 1 (PD-L1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) inhibitors has …

Predictive biomarkers of immune checkpoint inhibitors-related toxicities

Y Xu, Y Fu, B Zhu, J Wang, B Zhang - Frontiers in Immunology, 2020 - frontiersin.org
The emergence and continuous development of immune checkpoint inhibitors (ICIs) therapy
brings a revolution in cancer therapy history, but the major hurdle associated with their …

[HTML][HTML] Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immune checkpoint inhibitor-related adverse events

JR Brahmer, H Abu-Sbeih, PA Ascierto… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Immune checkpoint inhibitors (ICIs) are the standard of care for the treatment of several
cancers. While these immunotherapies have improved patient outcomes in many clinical …

[HTML][HTML] The mechanism and risk factors for immune checkpoint inhibitor pneumonitis in non-small cell lung cancer patients

X Zhai, J Zhang, Y Tian, J Li, W Jing… - Cancer Biology & …, 2020 - ncbi.nlm.nih.gov
Immune checkpoint inhibitors (ICIs) are new and promising therapeutic agents for non-small
cell lung cancer (NSCLC). However, along with demonstrating remarkable efficacy, ICIs can …

Differentiation between immune checkpoint inhibitor‐related and radiation pneumonitis in lung cancer by CT radiomics and machine learning

J Cheng, Y Pan, W Huang, K Huang, Y Cui… - Medical …, 2022 - Wiley Online Library
Purpose Consolidation immunotherapy after completion of chemoradiotherapy has become
the standard of care for unresectable locally advanced non‐small cell lung cancer and can …

Therapeutic and prognostic implications of immune-related adverse events in advanced non-small-cell lung cancer

L Daniello, M Elshiaty, F Bozorgmehr, J Kuon… - Frontiers in …, 2021 - frontiersin.org
Introduction PD-(L) 1 inhibitors have improved prognosis of non-small-cell lung cancer
(NSCLC), but can also cause immune-related adverse events (irAEs) that complicate …

Pulmonary toxicity of systemic lung cancer therapy

K Long, K Suresh - Respirology, 2020 - Wiley Online Library
Lung cancer is the leading cause of cancer‐related deaths worldwide. As new therapies are
developed, it is important to understand the pulmonary toxicities associated with systemic …

Development and validation of a radiomics nomogram using computed tomography for differentiating immune checkpoint inhibitor-related pneumonitis from radiation …

Q Qiu, L Xing, Y Wang, A Feng, Q Wen - Frontiers in Immunology, 2022 - frontiersin.org
Background The combination of immunotherapy and chemoradiotherapy has become the
standard therapeutic strategy for patients with unresected locally advance-stage non-small …

Clinical diagnosis and treatment of immune checkpoint inhibitor‐associated pneumonitis

H Wang, X Guo, J Zhou, Y Li, L Duan, X Si… - Thoracic …, 2020 - Wiley Online Library
The increasing use of immune checkpoint inhibitors in tumors has brought new hope of
survival to patients with advanced tumors. However, the immune system activated by …

Radiation versus immune checkpoint inhibitor associated pneumonitis: distinct radiologic morphologies

X Chen, K Sheikh, E Nakajima, CT Lin, J Lee… - The …, 2021 - academic.oup.com
Background Patients with non-small cell lung cancer may develop pneumonitis after thoracic
radiotherapy (RT) and immune checkpoint inhibitors (ICIs). We hypothesized that distinct …