Increased glutamine metabolism (glutaminolysis) is a hallmark of cancer and is recognised
as a key metabolic change in cancer cells. Breast cancer is a heterogeneous disease with …

Metabolic reprogramming is a hallmark of cancer development, progression, and
metastasis. Several metabolic pathways such as glycolysis, tricarboxylic acid (TCA) cycle …

Tumour cells frequently utilize glutamine to meet bioenergetic and biosynthetic demands of
rapid cell growth. However, glutamine dependence can be highly variable between in vitro …

Triple-negative breast cancers (TNBCs) lack progesterone and estrogen receptors and do
not have amplified human epidermal growth factor receptor 2, the main therapeutic targets …

Breast cancer is one of the most common malignancies that seriously threaten women's
health. In the process of the malignant transformation of breast cancer, metabolic …

Abstract The cyclin D1-Cyclin-Dependent Kinases 4 and 6 (CDK4/6) complex is crucial for
the development of melanoma. We previously demonstrated that targeting CDK4/6 using …

Ischemic episodes are a leading cause of death worldwide with limited therapeutic
interventions. The current study explored mitochondrial phosphate-activated glutaminase …

The glutaminase (GLS) enzyme hydrolyzes glutamine into glutamate, an important
anaplerotic source for the tricarboxylic acid cycle in rapidly growing cancer cells under the …

Vascular smooth muscle cells (VSMCs) are the predominant cell type in the media of the
blood vessels and are responsible for maintaining vascular tone. Emerging evidence …

Alternative splicing (AS) can generate distinct transcripts and subsequent isoforms that play
differential functions from the same pre-mRNA. Recently, increasing numbers of studies …