Cholangiocarcinoma (CCA) is an aggressive cancer arising from epithelial cells of the bile
duct. Most patients with CCA have an unresectable tumor at the time of diagnosis. In …

The omics technologies have improved our understanding of the molecular events that
underpin host–parasite interactions and the pathogenesis of parasitic diseases. In the last …

Fasciola gigantica is the causative organism of fascioliasis and is responsible for major
economic losses in livestock production globally. F. gigantica thioredoxin1 (FgTrx1) is an …

Chronic infection with the food-borne liver fluke, Opisthorchis viverrini, frequently induces
cancer of the bile ducts, cholangiocarcinoma. Opisthorchiasis is endemic in Thailand, Lao …

Clonorchis sinensis is a carcinogenic human liver fluke that promotes hepatic inflammatory
environments via direct contact or through their excretory-secretory products (ESPs) …

Innate, inflammatory responses towards persistent Opisthorchis viverrini (OV) infection are
likely to contribute to the development of cholangiocarcinoma (CCA), a liver cancer that is …

Peroxiredoxins (Prxs) are ubiquitary proteins able to play multiple physiological roles, that
include thiol-dependent peroxidase, chaperone holdase, sensor of H 2 O 2, regulator of H 2 …

Parasitic flukes are exposed to free radicals and, to a greater extent, reactive oxygen
species (ROS) during their life cycle. Despite being relentlessly exposed to ROS released by …

Millions of people are infected with the liver fluke, Opisthorchis viverrini (OV), but only~ 25%
of those infected develop liver disease and even fewer develop cholangiocarcinoma. The …

Cholangiocarcinoma (CCA) is a prevalent cancer in Southeast Asia, with Opisthorchis
viverrini (O. viverrini) infection being the primary risk factor. Most CCA cases in this region …