Precision oncology continues to challenge the “one-size-fits-all” dogma. Under the precision
oncology banner, cancer patients are screened for molecular tumor alterations that predict …

Various concentration gradient generation methods based on microfluidic systems are
summarized in this paper. The review covers typical structural characteristics, gradient …

Polydimethylsiloxane (PDMS) is nearly ubiquitous in microfluidic devices, being easy to
work with, economical, and transparent. A detailed protocol is provided here for using PDMS …

Pseudomonads sense changes in the concentration of chemicals in their environment and
exhibit a behavioral response mediated by flagella or pili coupled with a chemosensory …

The field of micro total analysis systems (μTAS)(1) or lab on a chip (LOC) has extended its
usefulness into many new fields and disciplines spanning basic research to commercial …

Molecular gradients play an important role in diverse physiological and pathological
phenomena such as immune response, wound healing, development and cancer …

Lab-on-a-chip technology is an emerging field evolving from the recent advances of micro-
and nanotechnologies. The technology allows the integration of various components into a …

Simple Summary Organoids, also known as self-organized 3D organ-like clusters, represent
almost a physiological system for studying cells, stem cells, tissues, and diseases, especially …

During tissue morphogenesis and homeostasis, cells experience various signals in their
environments, including gradients of physical and chemical cues. Spatial and temporal …

This paper reviews the latest developments in the design and fabrication of concentration
gradient generators for microfluidics-based biological applications. New gradient generator …