Growth factors play important roles in synapse formation. Mouse models of neuropsychiatric
diseases suggest that defects in synaptogenic growth factors, their receptors, and signaling …

This study aimed to explore the neurotoxic effects of 27-hydroxycholesterol (27-OHC), a
major circulating cholesterol active derivative in brain on synaptic structural and functional …

Adducin is a ubiquitously expressed actin-and spectrin-binding protein involved in
cytoskeleton organization, and is regulated through phosphorylation of the myristoylated …

Glioblastoma is a major unmet clinical need characterized by striking inter-and intra-tumoral
heterogeneity and a population of glioblastoma stem cells (GSCs), conferring …

Cholesterol plays an important role in synaptic plasticity, learning and memory. To better
explore how dietary cholesterol contributes to learning and memory and the related changes …

Secreted amyloid precursor protein alpha (sAPPα) processed from a parent human brain
protein, APP, can modulate learning and memory. It has potential for development as a …

Objective: To observe the effect of pregnenolone (PREG) intervention on the cholinergic
system function and the synaptic protein 1 (SYP1) expression in different brain regions of …

Citation: Peppercorn K, Kleffmann T, Jones O, Hughes S and Tate W (2022) Secreted
Amyloid Precursor Protein Alpha, a Neuroprotective Protein in the Brain Has Widespread …

Although actin is well recognized as a key player in axonal growth, how different actin-
binding proteins control its dynamics is still not fully understood. In the adult CNS axonal …

Although actin is well recognized as a key player in axonal growth, how different actin-
binding proteins control its dynamics is still not fully understood. In the adult CNS axonal …