Osteochondral defects are caused by injury to both the articular cartilage and subchondral
bone within skeletal joints. They can lead to irreversible joint damage and increase the risk …

Phenotypic plasticity, or adaptability, of a cell determines its ability to survive and function
within changing cellular environments. Changes in the mechanical environment, ranging …

Cartilage equivalents from hydrogels containing chondrocytes exhibit excellent potential in
hyaline cartilage regeneration, yet current approaches have limited success at reconstituting …

It is increasingly appreciated that the cell nucleus is not only a home for DNA but also a
complex material that resists physical deformations and dynamically responds to external …

The possibility of using protein-based materials as cellular scaffold strongly depends on
protein conformation, and several attempts have been made by researchers to obtain …

Autologous chondrocyte implantation (ACI) is a cell therapy to repair cartilage defects. In ACI
a biopsy is taken from a non-load bearing area of the knee and expanded in-vitro. The …

Cells are continuously exposed to dynamic environmental cues that influence their behavior.
Mechanical cues can influence cellular and genomic architecture, gene expression, and …

Stable cartilage regeneration in immunocompetent animals remains a huge challenge,
mainly ascribing to the in vivo implantation of tissue-engineered cartilage inevitably …

The success of cell-based approaches for the treatment of cartilage or fibro-cartilaginous
tissue defects requires an optimal cell source with chondrogenic differentiation ability that …

Articular cartilage is comprised of two main components, the extracellular matrix (ECM) and
the pericellular matrix (PCM). The PCM helps to protect chondrocytes in the cartilage from …