The identification of key genes in transcriptomic data constitutes a huge challenge. Our
review of microarray reports revealed 88 genes whose transcription is consistently regulated …

Abstract Development and progression of cancer are mediated by alterations in
transcriptional networks, resulting in a disturbed balance between the activity of oncogenes …

Gene expression profiling has uncovered the transcription factor Sox4 with upregulated
activity during TGF-β-induced epithelial-mesenchymal transition (EMT) in normal and …

Prostate cancer is the most commonly diagnosed noncutaneous neoplasm and second most
common cause of cancer-related mortality in western men. To investigate the mechanisms of …

Abstract Background Long non-coding RNAs (lncRNAs) play a variety of cellular roles,
including regulation of transcription and translation, leading to alterations in gene …

The human transcription factor SOX4 was 5-fold up-regulated in bladder tumors compared
with normal tissue based on whole-genome expression profiling of 166 clinical bladder …

DNA damage response (DDR) acts as a tumorigenesis barrier, and any defects in the DDR
machinery may lead to cancer. SOX4 expression is elevated in many types of tumors; …

Background and aims: The underlying molecular mechanisms of hepatocellular carcinoma
(HCC) remain poorly understood due to its complex development process. The human T cell …

Investigating the interaction of human endometrium and trophoblast during implantation is
difficult in vitro and impossible in vivo. This study was designed to analyze the effect of …

The transcription factor Sox4 is vital for fetal development, as Sox4–/–homozygotes die in
utero. Sox4 mRNA is expressed in the early embryonic growth plate and is regulated by …