Introduction Chronic infection with the protozoal parasite Trypanosoma cruzi leads to a
progressive cardiac disease, known as chronic Chagasic cardiomyopathy (CCC). A new …

Introduction Chagas disease, caused by chronic infection with the protozoan parasite
Trypanosoma cruzi, affects 6-7 million people worldwide. The major clinical manifestation of …

Simple Summary We used the dextran sodium sulfate (DSS) murine model of colitis, which
is widely used in preclinical studies, to determine the contribution of STAT3 to IBD. STAT3 …

Background Chagas disease, chronic infection with Trypanosoma cruzi, mainly manifests as
cardiac disease. However, the liver is important for both controlling parasite burdens and …

Signal transducer and activator of transcription (STAT) 3 has been assigned to the group of
“undruggable” disease-causing proteins, despite its containing a Src-homology (SH) 2 …

Introduction Hookworms are parasitic helminths that secrete a variety of proteins that induce
anti-inflammatory immune responses, stimulating increased CD4+ Foxp3+ regulatory T cells …

Initial studies using bioinformatics analysis revealed DNA sequence similarities between
Trypanosoma cruzi GenBank® M21331, coding for Antigen 36 (Ag 36), and tripartite motif …

Trypanosoma cruzi is the causative protozoan of Chagas' Disease, a neglected tropical
disease that affects 6− 7 million people worldwide. Interaction of the parasite with the host …

Trypanosoma cruzi, the etiological agent of Chagas disease, is an intracellular protozoan
parasite, which is now present in most industrialized countries. About 40% of T. cruzi …

Background Chagas disease, chronic infection with Trypanosoma cruzi, mainly manifests as
cardiac disease. However, the liver is important for both controlling parasite burdens and …