Choline is an essential nutrient for humans. It is a precursor of membrane phospholipids (eg,
phosphatidylcholine (PC)), the neurotransmitter acetylcholine, and via betaine, the methyl …

Epigenetic mechanisms, which include DNA methylation, a variety of post-translational
modifications of histone proteins (acetylation, phosphorylation, methylation, ubiquitination …

Epigenetic modifications such as histone methylation permit change in chromatin structure
without accompanying change in the underlying genomic sequence. A number of studies in …

In the past few decades, the field of neuroepigenetics has investigated how the brain
encodes information to form long-lasting memories that lead to stable changes in behaviour …

Intellectual disability (ID) is a prevailing neurodevelopmental condition associated with
impaired cognitive and adaptive behaviors. Many chromatin-modifying enzymes and other …

The past decade has produced an explosion in the number and variety of genetic tools
available to neuroscientists, resulting in an unprecedented ability to precisely manipulate …

Whole-exome sequencing (WES) is useful for molecular diagnosis, family genetic
counseling, and prognosis of intellectual disability (ID). However, ID molecular diagnosis …

Many studies have been written on vitamin supplementation, fatty acid, and dementia, but
results are still under debate, and no definite conclusion has yet been drawn. Nevertheless …

Background Posttranslational histone modifications play a critical role in the regulation of
gene transcription underlying synaptic plasticity and memory formation. One such epigenetic …

Autism spectrum disorder (ASD) is a constellation of neurodevelopmental disorders with
high phenotypic and genetic heterogeneity, complicating the discovery of causative genes …