Despite not being utilized as considerably as other antidepressants in the therapy of
depression, the monoamine oxidase inhibitors (MAOIs) proceed to hold a place in …

Monoamine oxidases (MAO-A and MAO-B) are mammalian flavoenzyme, which catalyze the
oxidative deamination of several neurotransmitters like norepinephrine, dopamine, tyramine …

Alzheimer disease (AD) is a frequent and devastating neurodegenerative disease in
humans, but still no curative treatment has been developed. Although many explicative …

Microglia and astrocytes play essential roles in the central nervous system contributing to
many functions including homeostasis, immune response, blood–brain barrier maintenance …

Fibromyalgia (FM) is a poorly understood chronic condition characterized by widespread
musculoskeletal pain, fatigue, and cognitive difficulties. While mounting evidence suggests a …

Background 18 F-THK5351 is a quinoline-derived tau imaging agent with high affinity to
paired helical filaments (PHF). However, high levels of 18 F-THK5351 retention in brain …

Acetylcholinesterase (AChE) enzyme inhibition is an important target for the management of
Alzheimer disease (AD) and AChE inhibitors are the main stay drugs for its management …

Reactive oxygen species (ROS) have been correlated with almost every human disease. Yet
clinical exploitation of these hypotheses by pharmacological modulation of ROS has been …

The dynamic and multicellular processes of neuroinflammation are mediated by the
nonneuronal cells of the central nervous system, which include astrocytes and the brain's …

Astrocytes colocalize with fibrillar amyloid-β (Aβ) plaques in postmortem Alzheimer disease
(AD) brain tissue. It is therefore of great interest to develop a PET tracer for visualizing …