Background Both fracture-related infections (FRIs) and periprosthetic joint infections (PJIs)
include orthopaedic implant-associated infections. However, key aspects of management …

Fracture-related infection (FRI) remains a challenging complication that imposes a heavy
burden on orthopaedic trauma patients. The surgical management eradicates the local …

Tuberculosis (TB) is the leading cause of death from a single infectious agent, requiring at
least 6 months of multidrug treatment to achieve cure. However, the lack of reliable data on …

Prosthetic Joint Infection (PJI) causes significant morbidity and mortality for patients globally.
Delivery of antibiotics to the site of infection has potential to improve the treatment outcomes …

Objectives The diagnosis of periprosthetic joint infection (PJI) is difficult and requires a
battery of tests and clinical findings. The purpose of this review is to summarize all current …

Antibiotics, by definition, reduce bacterial growth rates in optimal culture conditions;
however, the real-world environments bacteria inhabit see rapid growth punctuated by …

Abstract Background Although the Musculoskeletal Infection Society introduced the use of
erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) as inflammatory markers …

Bone cement is used as a mortar for securing bone implants, as bone void fillers or as
spacers in orthopaedic surgery. Antibiotic-loaded bone cements (ALBCs) have been used to …

Abstract β-lactam antibiotics, such as penicillin share a very unstable chemical structure. In
water-based solutions, such as those used for clinical applications, the β-lactam ring is …

Implantable orthopedic devices have had an enormously positive impact on human health;
however, despite best practice, patients are prone to developing orthopedic device-related …