Currently available synthetic grafts have contributed to improved outcomes in cardiovascular
surgery. However, the implementation of these graft materials at small diameters have …

Cardiovascular disease leads to the highest morbidity worldwide. There is an urgent need to
solve the lack of a viable arterial graft for patients requiring coronary artery bypass surgery …

We developed a tissue-engineered vascular graft (TEVG) for use in children and present
results of a US Food and Drug Administration (FDA)–approved clinical trial evaluating this …

For over 25 years, our group has used regenerative medicine strategies to develop
improved biomaterials for use in congenital heart surgery. Among other applications, we …

Vascular grafts are widely used for vascular surgeries, to bypass a diseased artery or
function as a vascular access for hemodialysis. Bioengineered or tissue-engineered …

The concept of tissue engineering evolved long before the phrase was forged, driven by the
thromboembolic complications associated with the early total artificial heart programs of the …

Vascular grafts (VG) are medical devices intended to replace the function of a diseased
vessel. Current approaches use non-biodegradable materials that struggle to maintain …

Blood vessels are subjected to complex biomechanical loads, primarily from pressure-driven
blood flow. Abnormal loading associated with vascular grafts, arising from altered …

Wall stress is often lower in tissue-engineered constructs than in comparable native tissues
due to the use of stiff polymeric materials having thicker walls. In this work, we sought to …

The advent of single-cell RNA sequencing (scRNA-Seq) has brought with it the ability to
gain greater insights into the cellular composition of tissues and heterogeneity in gene …