Chronic liver diseases include a broad group of hepatic disorders from different etiologies
and with varying degrees of progression and severity. Among them, non-alcoholic fatty …

Glutamine synthetase (GS) catalyzes de novo synthesis of glutamine that facilitates cancer
cell growth. In the liver, GS functions next to the urea cycle to remove ammonia waste. As a …

Hyperammonemia is the pathological accumulation of ammonia in the blood, which can
occur in many different clinical settings. Most commonly in adults, hyperammonemia occurs …

Carnitine acyl‐carnitine translocase deficiency (CACTD) is a rare autosomal recessive
disorder of mitochondrial long‐chain fatty‐acid transport. Most patients present in the first 2 …

Glutamine synthetase (GS) plays a crucial role in the homeostasis of the glutamate–
glutamine cycle in the brain. Hypoactive GS causes depressive behaviors. Under chronic …

Glutamine synthetase (GS) is a ubiquitous enzyme central to nitrogen metabolism,
catalyzing the ATP-dependent formation of glutamine from glutamate and ammonia …

Hyperammonemia after lung transplantation is a rare but potentially fatal condition. A 59-
year-old male patient affected by pulmonary fibrosis underwent an uncomplicated bilateral …

BACKGROUND Hepatic ischemia-reperfusion injury (IRI) poses a great challenge in liver
surgery and transplantation because of oxidative stress and inflammatory responses. The …

Background: The prognosis of cancers is strongly connected with nitrogen metabolism (NM),
which plays a critical role in the microenvironment and growth of tumors. It is …

Lactulose: A treatment for hyperammonemia in a lysinuric protein–intolerant patient with
dynamic blood amino acid concentrations - PMC Back to Top Skip to main content NIH NLM …