Pyridine and its derivatives are the important chemical compounds with tremendous
applications in the various fields. In this review we have summarized the medicinal and non …

Pyridone core structure has attracted much attention due to its abundance in natural
products of biological importance. 2-Pyridone derivatives display diverse biological …

Amino-3-methyl-1-phenyl-1 H-pyrazole-4-carbonitrile (1) was used as a precursor for
preparation of 3-methyl-1-phenyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one (2) and its …

Periodontal disease (PD) is complex polymicrobial disease which destroys tooth-supporting
tissue. Although various synthetic inhibitors of periodontitis-triggering pathogens have been …

A new class of cyanopyridine derivatives (10a–e and 11a–e) containing the phenylurea unit
was synthesized and tested against some metabolic enzymes including …

(4-Chlorophenyl)-3-cyano-6-(thien-2-yl)-1H-pyridin-2-one (2) was obtained by reaction of 2-
acetyl thiophene with 4-chlorobenzaldehyde and ethyl cyanoacetate in presence of …

VEGFR-2 is a key regulator in cancer angiogenesis. This research displays the design and
synthesis of novel 3-cyano-6-naphthylpyridine scaffold-based derivatives as selective …

A novel series of five or six new nitrogenated heterocyclic compounds were obtained by
reacting a chalcone derivative of 3-acetylindole with various reagents such as malononitrile …

Several studies on nicotinonitrile and their derivatives because of their wide range of
therapeutic activities have been reported. Many drugs containing nicotinonitrile derivatives …

Pyridines have occupied a unique place in medicinal chemistry as it is widely profound as
natural products and formed the integral backbone of great number of drugs in the market. In …