Protein N-glycosylation is one of the major post-translational modifications in eukaryotic
cells. In lower unicellular eukaryotes, the known functions of N-glycans are predominantly in …

The endoplasmic reticulum (ER) is a major site for protein synthesis, folding, and maturation
in eukaryotic cells, responsible for production of secretory proteins and most integral …

Protein synthesis, transport, and N-glycosylation are coupled at the mammalian
endoplasmic reticulum by complex formation of a ribosome, the Sec61 protein-conducting …

Oligosaccharyltransferase (OST) catalyzes the transfer of a high-mannose glycan onto
secretory proteins in the endoplasmic reticulum. Mammals express two distinct OST …

Oligosaccharyltransferase (OST) is an essential membrane protein complex in the
endoplasmic reticulum, where it transfers an oligosaccharide from a dolichol-pyrophosphate …

N-glycosylation is a ubiquitous modification of eukaryotic secretory and membrane-bound
proteins; about 90% of glycoproteins are N-glycosylated. The reaction is catalysed by an …

With faithful sample preservation and direct imaging of fully hydrated biological material,
cryo-electron tomography provides an accurate representation of molecular architecture of …

Congenital disorders of glycosylation (CDG) are a group of rare metabolic diseases, due to
impaired protein and lipid glycosylation. We identified two patients with defective serum …

Oligosaccharyltransferase (OST) is a multi-span membrane protein complex that catalyzes
the addition of glycans to selected Asn residues within nascent polypeptides in the lumen of …

Asparagine-linked glycosylation, also known as N-linked glycosylation is an essential and
highly conserved post-translational protein modification that occurs in all three domains of …