The regulatory actions of adenosine are mediated via four subtypes of G protein-coupled
receptors distinguished as A 1, A 2A, A 2B and A 3 receptors. Their presence on basically …

The natural plant alkaloids caffeine and theophylline were the first adenosine receptor (AR)
antagonists described in the literature. They exhibit micromolar affinities and are non …

Water-soluble prodrugs of potent, A2A-selective adenosine receptor (AR) antagonists were
prepared. 8-(m-Bromostyryl)-3, 7-dimethyl-1-propargylxanthine (BS-DMPX, 11) and the …

Ever since the discovery of the hypotensive and bradycardiac effects of adenosine,
adenosine receptors continue to represent promising drug targets. First, this is due to the fact …

3-Unsubstituted xanthine derivatives bearing a cyclopentyl or a phenyl residue in the 8-
position were synthesized and developed as A2B adenosine receptor antagonists …

Adenosine compartmentalization has a profound impact on immune cell function by
regulating adenosine localization and, therefore, extracellular signaling capabilities, which …

Intense efforts of many pharmaceutical companies and academicians in the A 1 adenosine
receptor (AR) field have led to the discovery of clinical candidates that are antagonists …

Drug addiction is a serious brain disorder with somatic, psychological, psychiatric, socio-
economic and legal implications in the developed world. Illegal (eg, psychostimulants …

The present study describes the preparation and binding properties of a new, potent, and
selective A2A adenosine receptor (AR) antagonist radioligand,[3H] 3-(3-hydroxypropyl)-7 …

Monoamine oxidase (MAO) is an important drug target for the treatment of neurological
disorders. A series of indole and benzofuran derivatives were synthesised and evaluated as …