In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …

This paper presents the 12th update of the human obesity gene map, which incorporates
published results up to the end of October 2005. Evidence from single‐gene mutation …

Agonists of mouse STING (TMEM173) shrink and even cure solid tumors by activating innate
immunity; human STING (hSTING) agonists are needed to test this therapeutic hypothesis in …

The idea for this book came from the time the authors spent at the Statistics and Applied
Mathematical Sciences Institute (SAMSI) in Research Triangle Park in North Carolina …

Obesity is a serious international health problem that increases the risk of several common
diseases. The genetic factors predisposing to obesity are poorly understood. A genome …

Type 2 diabetes mellitus results from the interaction of environmental factors with a
combination of genetic variants, most of which were hitherto unknown. A systematic search …

Until just a few years ago, the genetic determinants of obesity and metabolic syndrome were
largely unknown, with the exception of a few forms of monogenic extreme obesity. Since …

The considerable range of observed phenotypic variation in human populations may reflect,
in part, distinctive processes of natural selection and adaptation to variable environmental …

Obesity is a major public health concern. This condition results from a constant and complex
interplay between predisposing genes and environmental stimuli. Current attempts to …

OBJECTIVE—Three independent studies have shown that variation in the fat mass and
obesity-associated (FTO) gene associates with BMI and obesity. In the present study, the …