A mechanistic understanding of catalytic organic reactions is crucial for the design of new
catalysts, modes of reactivity and the development of greener and more sustainable …

Although Suzuki–Miyaura cross-coupling is one of the most convenient and well-developed
cross-coupling reactions, its applications to the asymmetric version to deliver highly …

Although computational contributions to the understanding of organometallic homogeneous
catalysts have become fairly routine, a step‐change in the application of computational …

Asymmetric ring-opening of 7-oxabenzonorbornadienes is achieved via Co-catalyzed indole
C–H functionalization. The utilization of chiral Co-catalyst consisting of a binaphthyl-derived …

In recent years, a variety of cycloalkyl groups with quaternary carbons, in particular
cyclopropyl and cyclobutyl trifluoromethyl groups, have emerged as promising bioisosteres …

Chemists have many options for elucidating reaction mechanisms. Global kinetic analysis
and classic transition-state probes (eg, LFERs, Eyring) inevitably form the cornerstone of any …

The involvement of planar carbocation intermediates is generally considered undesirable in
asymmetric catalysis due to the difficulty in gaining facial control and their intrinsic stability …

Abstract Asymmetric Suzuki–Miyaura cross-couplings with aryl boronic acids and allylic
electrophiles are a powerful method to convert racemic mixtures into enantioenriched …

The enantioconvergent radical Suzuki–Miyaura cross-coupling of racemic alkyl halides
represents a powerful approach for the construction of valuable C (sp3)–C bonds. In this …

Csp2–Csp2 Suzuki–Miyaura couplings (SMCs) are ubiquitous in the synthesis of small
molecules, but analogous Csp2–Csp3 bond-forming SMCs are rare, especially asymmetric …