Extracellular vesicles are released by the majority of cell types and circulate in body fluids.
They function as a long-distance cell-to-cell communication mechanism that modulates the …

Degenerative disorders of joints, especially osteoarthritis (OA), result in persistent pain and
disability and high costs to society. Nevertheless, the molecular mechanisms of OA have not …

Transplantation of synovial fluid-derived mesenchymal stem cells (SF-MSCs) is a viable
therapy for cartilage degeneration of osteoarthritis (OA). But controlling chondrogenic …

Background This study aimed to investigate the effect of bone marrow mesenchymal stem
cell (BMSC)-derived exosome injection on cartilage damage and pain relief in both in vitro …

Mitochondrial dysfunction and oxidative stress damage are hallmarks of osteoarthritis (OA).
Mesenchymal stem cell (MSC)-derived exosomes are important in intercellular mitochondria …

Background WNT5A is known to be involved in the pathogenesis of osteoarthritis. This study
investigated the molecular mechanism of exosomal miR-92a-3p and WNT5A in …

OBJECTIVES: Osteoarthritis (OA) is the most common joint disease throughout the world.
Exosomes derived from miR-140-5p-overexpressing synovial mesenchymal stem cells …

Extracellular vesicles (EVs) are cell-derived membrane-enclosed particles that are involved
in physiologic and pathologic processes. EVs are increasingly being studied for therapeutic …

Articular cartilage defect repair is a problem that has long plagued clinicians. Although
mesenchymal stem cells (MSCs) have the potential to regenerate articular cartilage, they …

Background Recently, accumulating evidence has shown that exosomes, the naturally
secreted nanocarriers of cells, can exert therapeutic effects in various disease models in the …