Clinical applications of next generation sequencing in cancer: from panels, to exomes, to genomes
This article will review recent impact of massively parallel next-generation sequencing
(NGS) in our understanding and treatment of cancer. While whole exome sequencing (WES) …
(NGS) in our understanding and treatment of cancer. While whole exome sequencing (WES) …
A review of cancer genetics and genomics studies in Africa
Cancer is the second leading cause of death globally and is projected to overtake infectious
disease as the leading cause of mortality in Africa within the next two decades. Cancer is a …
disease as the leading cause of mortality in Africa within the next two decades. Cancer is a …
Prevalence of Clinically Relevant Germline BRCA Variants in a Large Unselected South African Breast and Ovarian Cancer Cohort: A Public Sector Experience
Breast cancer is a multifaceted disease that currently represents a leading cause of death in
women worldwide. Over the past two decades (1998–2020), the National Health Laboratory …
women worldwide. Over the past two decades (1998–2020), the National Health Laboratory …
Germline mutations in 40 cancer susceptibility genes among C hinese patients with high hereditary risk breast cancer
Multigene panel testing of breast cancer predisposition genes have been extensively
conducted in Europe and America, which is relatively rare in Asia however. In this study, we …
conducted in Europe and America, which is relatively rare in Asia however. In this study, we …
Prevalence of specific and recurrent/founder pathogenic variants in BRCA genes in breast and ovarian cancer in North Africa
O ElBiad, A Laraqui, F El Boukhrissi, C Mounjid… - BMC cancer, 2022 - Springer
Background Elucidation of specific and recurrent/founder pathogenic variants (PVs) in
BRCA (BRCA1 and BRCA2) genes can make the genetic testing, for breast cancer (BC) …
BRCA (BRCA1 and BRCA2) genes can make the genetic testing, for breast cancer (BC) …
Nutrition in the prevention of breast Cancer: a middle eastern perspective
F Naja, L Nasreddine, S Awada… - Frontiers in public …, 2019 - frontiersin.org
This paper reviews the escalating burden of breast cancer (BC) in the Middle East (ME) and
the prevalence of modifiable risk factors and underscores opportunities to promote the …
the prevalence of modifiable risk factors and underscores opportunities to promote the …
Novel and recurrent BRCA1/BRCA2 germline mutations in patients with breast/ovarian cancer: a series from the south of Tunisia
D Ben Ayed-Guerfali, W Ben Kridis-Rejab… - Journal of Translational …, 2021 - Springer
Background The incidence of breast cancer (BC) and/or ovarian cancer (OC) is increasing in
Tunisia especially in young women and mostly those with family history. However, the …
Tunisia especially in young women and mostly those with family history. However, the …
Genetic epidemiology of ovarian cancer in the 22 Arab countries: a systematic review
Ovarian cancer (OC) is a common disease among Arabs, with one of the highest incidences
in the world. OC is underdiagnosed, underreported, and mostly reported with breast cancer …
in the world. OC is underdiagnosed, underreported, and mostly reported with breast cancer …
BRCA1 mutation spectrum, functions, and therapeutic strategies: The story so far
BRCA1 gene mutations account for about 25-28% of hereditary Breast Cancer as BRCA1 is
included in the category of high penetrance genes. Except for few commonmutations, there …
included in the category of high penetrance genes. Except for few commonmutations, there …
Genetics of breast cancer in African populations: a literature review
A Abbad, H Baba, H Dehbi… - Global health …, 2018 - cambridge.org
Breast cancer (BC) is one of the most complex, diverse and leading cause of death in
women worldwide. The present investigation aims to explore genes panel associated with …
women worldwide. The present investigation aims to explore genes panel associated with …