Current Development of Thiazole-Containing Compounds as Potential Antibacterials against Methicillin-Resistant Staphylococcus aureus

H Liu, T Xu, Z Xue, M Huang, T Wang… - ACS Infectious …, 2024 - ACS Publications
The emergence of multi-drug-resistant bacteria is threatening to human health and life
around the world. In particular, methicillin-resistant Staphylococcus aureus (MRSA) causes …

Thiazole-based analogs as potential antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA) and their SAR elucidation

J Guo, Z Xie, W Ruan, Q Tang, D Qiao, W Zhu - European Journal of …, 2023 - Elsevier
In recent years, the overuse of antibiotics has resulted in the emergence of antibiotic
resistance, which is a serious global health problem. Methicillin-resistant Staphylococcus …

Structure-activity relationship studies of thiazole agents with potential anti methicillin-resistance Staphylococcus aureus (MRSA) activity

J Wang, S Long, Z Liu, KP Rakesh, R Verma… - Process …, 2023 - Elsevier
Due to the increasing resistance of methicillin-resistant Staphylococcus aureus (MRSA) to
conventional antibiotics, further efforts are needed to develop new antimicrobial agents …

The bioactivity of thiazolidin-4-ones: A short review of the most recent studies

D Mech, A Kurowska, N Trotsko - International Journal of Molecular …, 2021 - mdpi.com
Thiazolidin-4-ones is an important heterocyclic ring system of a pharmacophore and a
privileged scaffold in medicinal chemistry. This review is focused on the latest scientific …

Fluorinated azoles as effective weapons in fight against methicillin-resistance staphylococcus aureus (MRSA) and its SAR studies

X Zhao, R Verma, MB Sridhara, KSS Kumar - Bioorganic Chemistry, 2024 - Elsevier
The rapid spread of Methicillin-resistant Staphylococcus aureus (MRSA) and its difficult-to-
treat skin and filmsy diseases are making MRSA a threat to human life. The most dangerous …

Potential Fluorinated Anti‐MRSA Thiazolidinone Derivatives with Antibacterial, Antitubercular Activity and Molecular Docking Studies

V Kumar, P Shetty, A HS, S Chandra K… - Chemistry & …, 2022 - Wiley Online Library
MRSA infection is one of the alarming diseases in the current scenario. Identifying newer
molecules to treat MRSA infection is of urgent need. In the present study, we have designed …

Recent insights into antibacterial potential of benzothiazole derivatives

P Kashyap, S Verma, P Gupta, R Narang, S Lal… - Medicinal Chemistry …, 2023 - Springer
Antimicrobial resistance (AMR) is a worldwide concern among infectious diseases due to
increased mortality, morbidity and treatment cost. According to WHO 2019 report, among the …

Molecular hybrids based on Pyrazole and 4-Thiazolidinone cores: Synthesis, characterization, and anticancer studies

M Mushtaque, MMA Rizvi - Journal of Molecular Structure, 2023 - Elsevier
A series of hybrid compounds (11a–d) bearing pyrazole (6a–d) and 4-thiazolidinone (10)
cores were synthesized and characterized. The molecular structure of the compounds was …

Review on the developments of benzothiazole-containing antimicrobial agents

M Haroun - Current Topics in Medicinal Chemistry, 2022 - ingentaconnect.com
The infectious diseases caused by bacterial resistance to antibiotics constitute an increasing
threat to human health on a global scale. An increasing number of infections, including …

Anti-tuberculosis Mur inhibitors: structural insights and the way ahead for development of novel agents

K Mehta, M Khambete, A Abhyankar, A Omri - Pharmaceuticals, 2023 - mdpi.com
Mur enzymes serve as critical molecular devices for the synthesis of UDP-MurNAc-
pentapeptide, the main building block of bacterial peptidoglycan polymer. These enzymes …