More than 50 years of research has yielded numerous Shigella vaccine candidates that
have exemplified both the promise of vaccine-induced prevention of shigellosis and the …

Shigella flexneri is a gram-negative bacterium which causes the most communicable of
bacterial dysenteries, shigellosis. Shigellosis causes 1.1 million deaths and over 164 million …

Shigella, a Gram‐negative invasive enteropathogenic bacterium, causes the rupture,
invasion and inflammatory destruction of the human colonic epithelium. This complex and …

Many preclinical studies in critical care medicine and related disciplines rely on hypothesis-
driven research in mice. The underlying premise posits that mice sufficiently emulate …

Renewed awareness of the substantial morbidity and mortality that Shigella infection causes
among young children in developing countries, combined with technological innovations in …

Shigella spp. are food-and waterborne pathogens that cause severe diarrheal and
dysenteric disease associated with high morbidity and mortality. Individuals most often …

Shigella is a leading cause of diarrhea among children globally and of diarrheal deaths
among children under 5 years of age in low-and middle-income countries. To date, no …

Shigella is the second most deadly diarrheal disease among children under five years of
age, after rotavirus, with high morbidity and mortality in developing countries. Currently, no …

Shigella is an important cause of diarrheal disease in young children living in developing
countries. No approved vaccines are available, and the development of vaccine candidates …

There is a need for vaccines effective against shigella infection in young children in resource-
limited areas. Protective immunity against shigella infection targets the O-specific …