Two billion people worldwide older than 18 years of age, or approximately 30% of the world
population, are overweight or obese. In addition, more than 43 million children under the …

Leptin, a 167-amino acid peptide hormone produced by white adipose tissue, is primarily
involved in the regulation of food intake and energy expenditure. Leptin receptors are …

Platelets play a variety of roles in vascular biology and are best recognized as primary
hemostasis and thrombosis mediators. Platelets have a large number of receptors and …

Leptin, a protein hormone produced by the adipocytes, has long been recognized to
regulate metabolism, neuroendorine and other physiological functions. Early findings of …

Thrombocytopenia has been consistently reported following the administration of adenoviral
gene transfer vectors. The mechanism underlying this phenomenon is currently unknown. In …

By catalyzing hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine
monophosphate (cGMP), cyclic nucleotide phosphodiesterases are critical regulators of their …

Globally, one of the major causes of death is the cardiovascular disease (CVD), and
platelets play an important role in thrombosis and atherosclerosis that led to death. Platelet …

Central obesity is a relevant risk factor for major cardiovascular events due to the
atherosclerotic involvement of coronary, cerebral and lower limb arterial vessels. A major …

A wealth of investigations, ranging from clinical and animal model studies to in vitro
analyses, have generated great interest in the cardiovascular effects of leptin. Accordingly …

Visceral adipose tissue (VAT) is a metabolic organ known to regulate fat mass, and glucose
and nutrient homeostasis. VAT is an active endocrine gland that synthesizes and secretes …