Blood viscosity is an important determinant of local flow characteristics, which exhibits shear
thinning behavior: it decreases exponentially with increasing shear rates. Both hematocrit …

Hematological diseases, due to their complex nature and diverse manifestations, pose
significant diagnostic challenges in healthcare. The pressing need for early and accurate …

It is well-established that patients with sickle cell disease (SCD) are at substantial risk of
neurological complications, including overt and silent stroke, microstructural injury, and …

Hypoxia is a common feature in children with sickle cell disease (SCD) that is inconsistently
associated with painful crises and acute chest syndrome. To assess the prevalence and risk …

Very few studies have investigated the effects of exercise on the biological parameters
involved in vaso‐occlusive events in sickle cell anaemia (SCA). The aim of this study was to …

The six-minute walk test is a well-established submaximal exercise reflecting the functional
status and the clinical severity of sickle cell patients. The aim of the present cross-sectional …

Chronic systemic inflammation is a pathophysiological feature of sickle cell disease (SCD).
Considering that regular exercise exerts multiple beneficial health effects including anti …

Vascular resistance and tissue perfusion may be both affected by impaired vascular function
and increased blood viscosity. Little is known about the effects of vascular function on the …

The present study investigated cerebral and muscle hemoglobin oxygen saturation (tissue
oxygen index, TOI) in children with sickle cell anemia (SS), sickle cell hemoglobin C disease …

Sickle cell disease (SCD) is a genetic disorder characterized by complex pathophysiological
mechanisms leading to vaso‐occlusive crisis, chronic pain, chronic hemolytic anemia, and …