Normal hypothalamopituitary development is closely related to that of the forebrain and is
dependent upon a complex genetic cascade of transcription factors and signaling molecules …

PITUITARY tumors are common neoplasms that exhibit a wide range of biological behavior,
in terms of hormonal and proliferative activities. Their hormonal activity is usually reflective of …

The pituitary gland has provided unique insight into molecular mechanisms and regulatory
factors controling both differentiation and gene transcription. We identified Tpit, a novel T …

Pitx2 is a homeodomain transcription factor that is mutated in Rieger syndrome, a
haploinsufficiency disorder affecting eyes and teeth. Pitx2 also has a postulated role in left …

Pitx1 is a Bicoid-related homeodomain factor that exhibits preferential expression in the
hindlimb, as well as expression in the developing anterior pituitary gland and first branchial …

The pituitary gland is a central endocrine organ regulating basic physiological functions,
including growth, the stress response, reproduction, metabolic homeostasis, and lactation …

Emergence of distinct cell types from a common primordium during pituitary development
occurs in response to opposing signaling gradients that induce an overlapping temporal and …

Salivary gland branching morphogenesis involves coordinated cell growth, proliferation,
differentiation, migration, apoptosis, and interaction of epithelial, mesenchymal, endothelial …

Since its discovery in the early 1990s, the orphan nuclear receptor SF-1 has been attributed
a central role in the development and differentiation of steroidogenic tissues. SF-1 controls …

The restricted expression of the Ptx1 (Pitx1) gene in the posterior half of the lateral plate
mesoderm has suggested that it may play a role in specification of posterior structures, in …