Heart disease and stroke statistics—2023 update: a report from the American Heart Association
CW Tsao, AW Aday, ZI Almarzooq, CAM Anderson… - Circulation, 2023 - Am Heart Assoc
Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …
Pathophysiology of hypertension: the mosaic theory and beyond
DG Harrison, TM Coffman, CS Wilcox - Circulation research, 2021 - Am Heart Assoc
Dr Irvine Page proposed the Mosaic Theory of Hypertension in the 1940s advocating that
hypertension is the result of many factors that interact to raise blood pressure and cause end …
hypertension is the result of many factors that interact to raise blood pressure and cause end …
Lifestyle management of hypertension: International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of …
Hypertension, defined as persistently elevated systolic blood pressure (SBP)> 140 mmHg
and/or diastolic blood pressure (DBP) at least 90 mmHg (International Society of …
and/or diastolic blood pressure (DBP) at least 90 mmHg (International Society of …
Polygenic risk scores for the prediction of cardiometabolic disease
Cardiometabolic diseases contribute more to global morbidity and mortality than any other
group of disorders. Polygenic risk scores (PRSs), the weighted summation of individually …
group of disorders. Polygenic risk scores (PRSs), the weighted summation of individually …
A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood
N Kurniansyah, MO Goodman, TN Kelly… - Nature …, 2022 - nature.com
In a multi-stage analysis of 52,436 individuals aged 17-90 across diverse cohorts and
biobanks, we train, test, and evaluate a polygenic risk score (PRS) for hypertension risk and …
biobanks, we train, test, and evaluate a polygenic risk score (PRS) for hypertension risk and …
Genetic predictors of lifelong medication-use patterns in cardiometabolic diseases
Little is known about the genetic determinants of medication use in preventing
cardiometabolic diseases. Using the Finnish nationwide drug purchase registry with follow …
cardiometabolic diseases. Using the Finnish nationwide drug purchase registry with follow …
Sex-specific genetic architecture of blood pressure
The genetic and genomic basis of sex differences in blood pressure (BP) traits remain
unstudied at scale. Here, we conducted sex-stratified and combined-sex genome-wide …
unstudied at scale. Here, we conducted sex-stratified and combined-sex genome-wide …
Associations of combined genetic and lifestyle risks with hypertension and home hypertension
M Takase, T Hirata, N Nakaya, T Nakamura… - Hypertension …, 2024 - nature.com
No study, to our knowledge, has constructed a polygenic risk score based on clinical blood
pressure and investigated the association of genetic and lifestyle risks with home …
pressure and investigated the association of genetic and lifestyle risks with home …
Measured blood pressure, genetically predicted blood pressure, and cardiovascular disease risk in the UK biobank
Importance Hypertension remains the major cardiovascular disease risk factor globally, but
variability in measured blood pressure may result in suboptimal management. Whether …
variability in measured blood pressure may result in suboptimal management. Whether …
Preeclampsia prediction using machine learning and polygenic risk scores from clinical and genetic risk factors in early and late pregnancies
VP Kovacheva, BW Eberhard, RY Cohen, M Maher… - …, 2024 - Am Heart Assoc
BACKGROUND: Preeclampsia, a pregnancy-specific condition associated with new-onset
hypertension after 20-weeks gestation, is a leading cause of maternal and neonatal …
hypertension after 20-weeks gestation, is a leading cause of maternal and neonatal …