Covering: up to 2024 Fe (II) and 2-oxoglutarate-dependent dioxygenases (Fe/2OG DOs) are
a superfamily of enzymes that play important roles in a variety of catalytic reactions …

Stabilization of hypoxia-inducible factor (HIF) by inhibiting prolyl hydroxylase domain
enzymes (PHDs) represents a breakthrough in treating anemia associated with chronic …

Human prolyl‐hydroxylases (PHDs) are hypoxia‐sensing 2‐oxoglutarate (2OG)
oxygenases, catalysis by which suppresses the transcription of hypoxia‐inducible factor …

Introduction: Hypoxia-inducible factor (HIF) prolyl hydroxylase domain (PHD) enzymes are
major therapeutic targets of anemia and ischemic/hypoxia diseases. To overcome safety …

The 2‐oxoglutarate‐dependent hypoxia inducible factor prolyl hydroxylases (PHDs) are
targets for treatment of a variety of diseases including anaemia. One PHD inhibitor is …

The human 2-oxoglutarate dependent oxygenase aspartate/asparagine-β-hydroxylase
(AspH) catalyses the hydroxylation of Asp/Asn-residues in epidermal growth factor-like …

Human aspartate/asparagine–β-hydroxylase (AspH) is a 2-oxoglutarate (2OG)–dependent
oxygenase that catalyzes the post-translational hydroxylation of Asp and Asn residues in …

Abstract A [3+ 1+ 1+ 1] cycloaddition was developed among 2‐arylpropene, ketone and
DMSO in the presence of K2S2O8. 2‐arylpropene provides three carbons, ketone offers one …

Abstract Prolyl hydroxylase 2 (PHD2) is a key oxygen receptor regulating oxygen
homeostasis in human body, and it is one of the important targets for drug research and …

Human aspartate/asparagine-βhydroxylase (AspH) is a 2-oxoglutarate (2OG) dependent
oxygenase that catalyzes the posttranslational hydroxylation of Asp-and Asnresidues in …