Intestinal stem cells at the bottom of crypts fuel the rapid renewal of the different cell types
that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of …

Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

The intestinal barrier is essential in human health and constitutes the interface between the
outside and the internal milieu of the body. A functional intestinal barrier allows absorption of …

The upper gastrointestinal tract, consisting of the esophagus, stomach, and duodenum,
controls food transport, digestion, nutrient uptake, and hormone production. By single-cell …

Developmental processes underlying normal tissue regeneration have been implicated in
cancer, but the degree of their enactment during tumor progression and under the selective …

Functional tissue regeneration is required for the restoration of normal organ homeostasis
after severe injury. Some organs, such as the intestine, harbour active stem cells throughout …

Cancer stem cells (CSCs) have been hypothesized to represent the driving force behind
tumour progression and metastasis, making them attractive cancer targets. However …

The mucosal lining of the gut has co-evolved with a diverse microbiota over millions of
years, leading to the development of specialized mechanisms to actively limit the invasion of …

Tissues have a natural capacity to replace dying cells and to heal wounds. This ability
resides in resident stem cells, which self-renew, preserve, and repair their tissue during …

Little is known about how metabolites couple tissue-specific stem cell function with
physiology. Here we show that, in the mammalian small intestine, the expression of Hmgcs2 …