Several dominantly inherited, late onset, neurodegenerative diseases are due to expansion
of CAG repeats, leading to expansion of glutamine repeats in the affected proteins. These …

Plant genomics projects involving model species and many agriculturally important crops
are resulting in a rapidly increasing database of genomic and expressed DNA sequences …

Two forms of the neurodegenerative disorder spinocerebellar ataxia are known to be
caused by the expansion of a CAG (polyglutamine) trinucleotide repeat. By screening cDNA …

Huntington's disease (HD) is a neurodegenerative disease caused by polyglutamine
expansion in the protein huntingtin (htt). Pathogenesis in HD appears to involve the …

Schizophrenia is one of the most common, devastating, and least understood
neuropsychiatric illnesses present in the human population. Despite decades of research …

Recently, moderate (CAG)> 20 repeat expansions in the α1A-voltage-dependent calcium
channel gene (CACNL1A4) have been identified in a previously unmapped type of SCA …

There are currently 13 diseases known to be caused by unstable triplet repeat mutations;
however, there are some instances (as with FRAXF and FRA16) when these mutations …

We have recently observed a large pedigree with a new rare autosomal dominant spastic
paraparesis. In three subsequent generations, 13 affected individuals presented with …

Twelve diseases, most with neuropsychiatric features, arise from trinucleotide repeat
expansion mutations. Expansion mutations may also cause a number of other disorders …

Huntington's disease (HD) is a neurodegenerative disease caused by polyglutamine (polyQ)
expansion in the protein huntingtin (htt). Pathogenesis in HD seems to involve the formation …