Abstract α-Synuclein is an abundant neuronal protein which localizes predominantly to
presynaptic terminals, and is strongly linked genetically and pathologically to Parkinson's …

Parkinson's disease (PD) is usually diagnosed through motor symptoms that make the
patient incapable of carrying out daily activities; however, numerous non-motor symptoms …

Substantial evidence links α-synuclein, a small highly conserved presynaptic protein with
unknown function, to both familial and sporadic Parkinson's disease (PD). α-Synuclein has …

Lipids in the brain are major components playing structural functions as well as
physiological roles in nerve cells, such as neural communication, neurogenesis, synaptic …

Aggregation of α‐synuclein, an abundant and conserved pre‐synaptic brain protein, is
implicated as a critical factor in several neurodegenerative diseases. These diseases …

The progressive loss of the nigrostriatal pathway is a distinguishing feature of Parkinson's
disease. As terminal field loss seems to precede cell body loss, we tested whether …

Membrane proteins participate in nearly all cellular processes; however, because of
experimental limitations, their characterization lags far behind that of soluble proteins …

Accumulation of the neuronal presynaptic protein alpha-synuclein within proteinaceous
inclusions represents the key histophathological hallmark of a spectrum of …

α-Synuclein (α-Syn), an intrinsically disordered protein, is associated with Parkinson's
disease. Though molecular pathogenic mechanisms are ill-defined, mounting evidence …

α-Synuclein (αS) is linked to Parkinson disease through its deposition in an amyloid fibril
form within Lewy Body deposits, and by the existence of three αS point mutations that lead to …