Parkinson's disease is a progressive neurodegenerative disorder. The classical motor
symptoms include resting tremors, bradykinesia, rigidity and postural instability and are …

Aggregation of alpha-synuclein into inclusion bodies, termed Lewy pathology, is a defining
feature of Parkinson's disease (PD) and Dementia with Lewy bodies (DLB). In the majority of …

Parkinson's disease (PD) is a neurodegenerative disease with a 200 year-long research
history. Our understanding about its clinical phenotype and pathogenesis remains limited …

The conversion of endogenous alpha-synuclein (asyn) to pathological asyn-enriched
aggregates is a hallmark of Parkinson's disease (PD). These inclusions can be detected in …

Objective Parkinson's disease (PD) may be caused by an enteric neurotropic pathogen
entering the brain through the vagal nerve, a process that may take over 20 years. We …

A new model of Parkinson's disease (PD) pathogenesis is proposed, the α-Synuclein Origin
site and Connectome (SOC) model, incorporating two aspects of α-synuclein pathobiology …

A relatively small number of especially susceptible nerve cell types within multiple
neurotransmitter systems of the human central, peripheral, and enteric nervous systems …

Human genetics has indicated a causal role for the protein α-synuclein in the pathogenesis
of familial Parkinson's disease (PD), and the aggregation of synuclein in essentially all …

The ultimate origin of Lewy body disorders, including Parkinson's disease (PD) and
Dementia with Lewy bodies (DLB), is still incompletely understood. Although a large number …

Parkinson's disease (PD) is the second most common neurodegenerative disease. PD
patients exhibit motor symptoms such as akinesia/bradykinesia, tremor, rigidity, and postural …