Lipids, as the basic component of cell membranes, play an important role in human health
as well as brain function. The brain is highly enriched in lipids, and disruption of lipid …

Many clinical and animal studies demonstrate the importance of long-chain polyunsaturated
fatty acids (LCPUFA) in neural development and neurodegeneration. This review will focus …

Docosahexaenoic acid (DHA), a polyunsaturated fatty acid (PUFA) enriched in
phospholipids in the brain and retina, is known to play multi-functional roles in brain health …

The impact of inflammation suppressor pathways on Alzheimer's disease (AD) evolution
remains poorly understood. Human genetic evidence suggests involvement of the cardinal …

C57Bl/6 mice were administered a high fat, Western diet (WD, 41% fat) or a very high fat lard
diet (HFL, 60% fat), and evaluated for cognitive ability using the Stone T-maze and for …

Alzheimer′ s disease (AD) is a progressive neurodegenerative disorder that accounts for
the major cause of dementia, and the increasing worldwide prevalence of AD is a major …

Progression of brain ageing is influenced by a complex interaction of genetic and
environmental factors. Analysis of genetically modified animals with uniform genetic …

In recent decades, the role of the peroxisome in physiology and disease conditions has
become increasingly important. Together with the mitochondria and other cellular …

The advent of highthroughput 'omics' technologies has improved our knowledge of gut
microbiome in human health and disease, including Alzheimer's disease (AD), a …

Reductions of baseline cerebral blood flow (CBF) of∼ 10–20% are a common symptom of
Alzheimer's disease (AD) that appear early in disease progression and correlate with the …