Complement: Bridging the innate and adaptive immune systems in sterile inflammation

MW Lo, TM Woodruff - Journal of Leucocyte Biology, 2020 - academic.oup.com
The complement system is a collection of soluble and membrane-bound proteins that
together act as a powerful amplifier of the innate and adaptive immune systems. Although its …

Advances in cutaneous squamous cell carcinoma management

C Burns, S Kubicki, QB Nguyen, N Aboul-Fettouh… - Cancers, 2022 - mdpi.com
Simple Summary Cutaneous squamous cell carcinoma (cSCC) is an increasingly prevalent
and morbid cancer worldwide. Management of this cancer has changed significantly in the …

Cell-free DNA as a solid-organ transplant biomarker: technologies and approaches

RL Edwards, J Menteer, RM Lestz… - Biomarkers in …, 2022 - Taylor & Francis
High-quality biomarkers that detect emergent graft damage and/or rejection after solid-organ
transplantation offer new opportunities to improve post-transplant monitoring, allow early …

Mean lifetime survival estimates following solid organ transplantation in the US and UK

CN Graham, C Watson, A Barlev… - Journal of Medical …, 2022 - Taylor & Francis
Aims Accurately estimating mean survival after solid organ transplant (SOT) is crucial for
efficient healthcare resource allocation decisions. However, registry-based post-transplant …

Predicting long-term outcomes of kidney transplantation in the era of artificial intelligence

S Badrouchi, MM Bacha, A Ahmed, T Ben Abdallah… - Scientific Reports, 2023 - nature.com
The ability to accurately predict long-term kidney transplant survival can assist nephrologists
in making therapeutic decisions. However, predicting kidney transplantation (KT) outcomes …

A machine learning framework for predicting long-term graft survival after kidney transplantation

S Badrouchi, A Ahmed, MM Bacha… - Expert Systems with …, 2021 - Elsevier
Kidney transplantation (KT) is an optimal treatment for end-stage renal disease (ESRD).
Currently, short-term KT outcomes are indeed excellent, but long-term successful outcomes …

Calcineurin inhibitors' impact on cardiovascular and renal function, a descriptive study in lung transplant recipients from the North of Spain

R Nogueiras-Álvarez, VM Mora-Cuesta… - Scientific Reports, 2022 - nature.com
Patients undergoing lung transplantation (LTx) need administration of immunosuppressive
therapy following the procedure to prevent graft rejection. However, these drugs are not …

Predictive value of chart‐based frailty evaluation for lung transplant candidates

S Gee, Y Lee, A Shah, E Izadmehr… - Clinical …, 2022 - Wiley Online Library
Frailty, defined as a state of decreased physiologic reserve, has been correlated with poorer
outcomes after hospitalization or surgery. Studies in lung transplant patients have …

Ferret lung transplantation models differential lymphoid aggregate morphology between restrictive and obstructive forms of chronic lung allograft dysfunction

TJ Lynch, BA Ahlers, AM Swatek, V Ievlev, AC Pai… - …, 2022 - journals.lww.com
Background. Long-term survival after lung transplantation remains limited by chronic lung
allograft dysfunction (CLAD). CLAD has 2 histologic phenotypes, namely obliterative …

A systematic overview of the spermatotoxic and genotoxic effects of methotrexate, ganciclovir and mycophenolate mofetil

NB Jensen, SD Justesen, A Larsen… - Acta Obstetricia et …, 2021 - Wiley Online Library
Introduction Immunosuppressant drugs are increasingly being used in the reproductive
years. Theoretically, such medications could affect fetal health either through changes in the …