BACKGROUND: Ca2+ is a ubiquitous and versatile second messenger that transmits
information through changes of the cytosolic Ca2+ concentration. Recent investigations …

The interactions between mathematics and physiology have a long and illustrious history, of
which the study of calcium signalling is but a small chapter. Nevertheless, for those involved …

The spatio-temporal behaviour of the intracellular calcium concentration is both
physiologically important and theoretically complex, and this has led to a large body of joint …

Ca2+ is a ubiquitous intracellular messenger that regulates diverse cellular activities.
Extracellular stimuli often evoke sequences of intracellular Ca2+ spikes, and spike …

In computational neuroscience integrate-and-fire models capture the spike generation by a
subthreshold dynamics supplemented by a simple fire-and-reset rule; they allow for a …

Cellular signaling systems precisely transmit information in the presence of molecular noise
while retaining flexibility to accommodate the needs of individual cells. To understand …

Abstract Inositol 1, 4, 5-trisphosphate-induced Ca 2+ signaling is a second messenger
system used by almost all eukaryotic cells. The agonist concentration stimulating Ca 2+ …

Receptor-mediated oscillations in cytosolic Ca 2+ concentration ([Ca 2+] i) could originate
either directly from an autonomous Ca 2+ feedback oscillator at the inositol 1, 4, 5 …

Complexity and limited knowledge render it impractical to write down the equations
describing a cellular system completely. Cellular biophysics uses hypotheses-based …

Puffs are local Ca 2+ signals that arise by Ca 2+ liberation from the endoplasmic reticulum
through concerted opening of tightly clustered inositol trisphosphate receptor/channels (IP 3 …