Accumulating evidence shows that deregulation of fatty acid (FA) metabolism is associated
with the development of cancer. Long-chain acyl-coenzyme A synthases (ACSLs) are …

Simple Summary The dysregulation of ACSL3 and ACSL4, which belong to the long-chain
fatty acyl CoA synthetase family (ACSLs), affects the behavior of various cancer cells. This …

Cancer is one of the leading causes of death globally, associated with multifactorial
pathophysiological components. In particular, genetic mutations, infection or inflammation …

Background Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell
lung cancer. Ferroptosis is a newly recognized process of cell death, which is different from …

Cancer cells frequently undergo metabolic reprogramming to support tumorigenicity and
malignancy, which is recognized as a hallmark of cancer. In addition to glycolysis and …

Breast and lung cancer are two of the most lethal forms of cancer, responsible for a
disproportionately high number of deaths worldwide. Both doctors and cancer patients …

Despite modern treatment, infertility remains one of the most common gynecologic diseases
causing severe health effects worldwide. The clinical and epidemiological data have shown …

Five acyl-CoA synthetase long-chain family members (ACSLs) are responsible for catalyzing
diverse long-chain fatty acids (LCFAs) into LCFA-acyl-coenzyme A (CoA) for their …

Lung cancer is a common neoplasm, usually treated through chemotherapy, radiotherapy
and/or surgery. Both clinical and experimental studies on cancer cells suggest that some …

A hallmark of cancer cells is their remarkable ability to efficiently adapt to favorable and
hostile environments. Due to a unique metabolic flexibility, tumor cells can grow even in the …