Glycosaminoglycans (GAGs) and proteoglycans (PGs) are essential components of the
extracellular matrix (ECM) with pivotal roles in cellular mechanosensing pathways. GAGs …

In recent decades, 3D bioprinting has garnered significant research attention due to its
ability to manipulate biomaterials and cells to create complex structures precisely. However …

The process in which locally confined epithelial malignancies progressively evolve into
invasive cancers is often promoted by unjamming, a phase transition from a solid-like to a …

Although sex differences have been noted in cellular function and behavior, therapy efficacy,
and disease incidence and outcomes, the adoption of sex as a biological variable in tissue …

By using a full factorial design of experiment, the combinatorial effects of biological sex,
shear stress, and substrate stiffness on human umbilical vein endothelial cell (HUVEC) …

Tissues grow and remodel in response to mechanical cues, extracellular and intracellular
signals experienced through various biological events, from the developing embryo to …

Although multiple regenerative strategies are being developed for periodontal
reconstruction, guided periodontal ligament (PDL) regeneration is difficult because of its …

Collagen plays a critical role in regulating breast cancer progression and therapeutic
resistance. An improved understanding of both the features and drivers of tumor-permissive …

Myofibroblasts are a highly secretory and contractile cell phenotype that are predominant in
wound healing and fibrotic disease. Traditionally, myofibroblasts are identified by the de …

Objectives Fibroses are disorders linked to persistence of myofibroblasts due to biochemical
(eg, Transforming growth factor-β) and biophysical cues (eg, a stiff microenvironment). In the …