Abstract Development of a cancer is a multistep process and six major hallmarks of cancer
that are known to control malignant transformation have been described. Anticancer drug …

Whole-exome sequencing of cell-free DNA (cfDNA) could enable comprehensive profiling of
tumors from blood but the genome-wide concordance between cfDNA and tumor biopsies is …

Mixed phenotype acute leukaemia (MPAL) is a high-risk subtype of leukaemia with myeloid
and lymphoid features, limited genetic characterization, and a lack of consensus regarding …

Allele-specific copy number analysis (ASCN) from next generation sequencing (NGS) data
can greatly extend the utility of NGS beyond the identification of mutations to precisely …

Spatial and temporal dissection of the genomic changes occurring during the evolution of
human non–small cell lung cancer (NSCLC) may help elucidate the basis for its dismal …

As more clinically relevant cancer genes are identified, comprehensive diagnostic
approaches are needed to match patients to therapies, raising the challenge of optimization …

Gastric cancer is a heterogeneous disease with diverse molecular and histological
subtypes. We performed whole-genome sequencing in 100 tumor-normal pairs, along with …

Next-generation sequencing (NGS) of cancer genomes promises to revolutionise oncology,
with the ability to design and use targeted drugs, to predict outcome and response, and to …

We introduce PyClone, a statistical model for inference of clonal population structures in
cancers. PyClone is a Bayesian clustering method for grouping sets of deeply sequenced …

We describe a computational method that infers tumor purity and malignant cell ploidy
directly from analysis of somatic DNA alterations. The method, named ABSOLUTE, can …