Amyloid-beta (Aß) and hyperphosphorylated tau are hallmark lesions of Alzheimer's disease
(AD). However, the loss of synapses and dysfunctions of neurotransmission are more …

The mechanistic target of rapamycin (mTOR) signaling pathway is a crucial cellular
signaling hub that, like the nervous system itself, integrates internal and external cues to …

Mammalian target of rapamycin (mTOR) is a protein kinase involved in translation control
and long-lasting synaptic plasticity. mTOR functions as the central component of two multi …

Hyperconnectivity of neuronal circuits due to increased synaptic protein synthesis is thought
to cause autism spectrum disorders (ASDs). The mammalian target of rapamycin (mTOR) is …

Long-lasting forms of synaptic plasticity and memory are dependent on new protein
synthesis. Recent advances obtained from genetic, physiological, pharmacological, and …

The mechanistic target of rapamycin (mTOR) acts as a highly conserved signaling “hub” that
integrates neuronal activity and a variety of synaptic inputs. mTOR is found in two …

The target of rapamycin (TOR) is a highly conserved serine/threonine kinase and a central
controller of cell growth, metabolism and aging. Mammalian TOR (mTOR) is activated in …

Activity-dependent changes in the strength of synaptic connections are fundamental to the
formation and maintenance of memory. The mechanisms underlying persistent changes in …

Autism spectrum disorders (ASDs) are an early onset, heterogeneous group of heritable
neuropsychiatric disorders with symptoms that include deficits in social interaction skills …

Strong evidence indicates that regulated mRNA translation in neuronal dendrites underlies
synaptic plasticity and brain development. The fragile X mental retardation protein (FMRP) is …