Centrioles/basal bodies (CBBs) are microtubule-based cylindrical organelles that nucleate
the formation of centrosomes, cilia, and flagella. CBBs, cilia, and flagella are ancestral …

The primary cilium organizes numerous signal transduction cascades, and an
understanding of signaling receptor trafficking to cilia is now emerging. A defining feature of …

Primary cilia are sensory organelles that translate extracellular chemical and mechanical
cues into cellular responses. Bone is an exquisitely mechanosensitive organ, and its …

Centrioles are vital cellular structures that form centrosomes and cilia. The formation and
function of cilia depends on a set of centriole's distal appendages. In this study, we use …

Cilia, either motile or immotile, exist on most cells in the human body. There are several
different mechanisms of ciliogenesis, which enable the production of many kinds of cilia and …

In most lineages, cell cycle exit is correlated with the growth of a primary cilium. We
analyzed cell cycle exit and ciliogenesis in human retinal cells and found that, contrary to the …

Mesenchymal stem cells (MSCs) from adult tissues are promising candidates for
personalized cell therapy and tissue engineering. Significant progress was achieved in our …

Bardet-Biedl syndrome (BBS) is an inherited ciliopathy generally associated with severe
obesity, but the underlying mechanism remains hypothetical and is generally proposed to be …

Cilia and flagella have essential functions in a wide range of organisms. Cilia assembly is
dynamic during development and different types of cilia are found in multicellular organisms …

Primary cilia are microtubule-based sensory organelles that play important roles in
development and disease [1]. They are required for Sonic hedgehog (Shh)[2–4] and platelet …