The oxygen cascade from atmosphere to mitochondria as a tool to understand the (mal) adaptation to hypoxia

M Samaja, S Ottolenghi - International Journal of Molecular Sciences, 2023 - mdpi.com
Hypoxia is a life-threatening challenge for about 1% of the world population, as well as a
contributor to high morbidity and mortality scores in patients affected by various …

Breaking mental barriers promotes recovery after spinal cord injury

HI Rodocker, A Bordbar, MJE Larson… - Frontiers in Molecular …, 2022 - frontiersin.org
Functional recovery after spinal cord injury (SCI) often proves difficult as physical and mental
barriers bar survivors from enacting their designated rehabilitation programs. We recently …

Airway basal cells mediate hypoxia-induced EMT by increasing ribosome biogenesis

Y Hou, Y Ding, D Du, T Yu, W Zhou, Y Cui… - Frontiers in …, 2021 - frontiersin.org
Excessive secretion of airway mucus and fluid accumulation are the common features of
many respiratory diseases, which, in turn, induce cell hypoxia in the airway epithelium …

TRPA1 as a O2 sensor detects microenvironmental hypoxia in the mice anterior cingulate cortex

R Kawabata, S Shimoyama, S Ueno, I Yao, A Arata… - Scientific Reports, 2023 - nature.com
Transient receptor potential ankyrin 1 (TRPA1) is a member of the TRP channel family and is
expressed in peripheral and central nervous systems. In the periphery, TRPA1 senses cold …

Hypoxia augments TRPM3-mediated calcium influx in vagal sensory neurons

KR Langen, HA Dantzler, PG de Barcellos-Filho… - Autonomic …, 2023 - Elsevier
Transient receptor potential melastatin 3 (TRPM3) channels contribute to nodose afferent
and brainstem nucleus tractus solitarii (nTS) activity. Exposure to short, sustained hypoxia …

TRPA1 channel in the airway underlies protection against airborne threats by modulating respiration and behaviour

T Kuwaki, N Takahashi - The Journal of Physiology, 2023 - Wiley Online Library
Transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily of cation
channels, is broadly expressed in sensory neural pathways, including the trigeminal …

Intrinsic diving reflex induces potent antioxidative response by activation of NRF2 signaling

K Powell, S Wadolowski, W Tambo, JJ Strohl, D Kim… - bioRxiv, 2024 - biorxiv.org
Aims: This study aims to elucidate the underlying mechanisms of diving reflex, a powerful
endogenous mechanism supporting underwater mammalian survival. Antioxidative …