Brain-derived neurotrophic factor rs6265 (Val66Met) single nucleotide polymorphism as a master modifier of human pathophysiology

B Hill, N Sims, A Heck, M Negron, C Lusk… - Neural Regeneration …, 2023 - journals.lww.com
Brain-derived neurotrophic factor is the most prevalent member of the nerve growth factor
family. Since its discovery in 1978, this enigmatic molecule has spawned more than 27,000 …

Enhancing effects of environmental enrichment on the functions of natural killer cells in mice

R Xiao, S Ali, MA Caligiuri, L Cao - Frontiers in immunology, 2021 - frontiersin.org
The environment of an organism can convey a powerful influence over its biology.
Environmental enrichment (EE), as a eustress model, has been used extensively in …

Irisin increases the expression of anorexigenic and neurotrophic genes in mouse brain

A Natalicchio, N Marrano, G Biondi… - Diabetes/Metabolism …, 2020 - Wiley Online Library
Background Irisin, a newly discovered muscle‐derived hormone, acts in different organs and
tissues, improving energy homeostasis. In this study, we assessed, for the first time, the …

Hypothalamic AAV-BDNF gene therapy improves metabolic function and behavior in the Magel2-null mouse model of Prader-Willi syndrome

NJ Queen, X Zou, JM Anderson, W Huang… - … Therapy-Methods & …, 2022 - cell.com
Individuals with Prader-Willi syndrome (PWS) display developmental delays, cognitive
impairment, excessive hunger, obesity, and various behavioral abnormalities. Current PWS …

Hypothalamic gene transfer of BDNF promotes healthy aging in mice

T McMurphy, W Huang, X Liu, JJ Siu, NJ Queen… - Aging …, 2019 - Wiley Online Library
The aging process and age‐related diseases all involve perturbed energy adaption and
impaired ability to cope with adversity. Brain‐derived neurotrophic factor (BDNF) in the …

Combined transcriptome and metabolome analysis reveals breed-specific regulatory mechanisms in Dorper and Tan sheep

Y Ma, G Cai, J Chen, X Yang, G Hua, D Han, X Li… - BMC genomics, 2024 - Springer
Abstract Background Dorper and Tan sheep are renowned for their rapid growth and
exceptional meat quality, respectively. Previous research has provided evidence of the …

MC4R in Central and Peripheral systems

R Wei, D Li, S Jia, Y Chen, J Wang - Advanced Biology, 2023 - Wiley Online Library
Obesity has emerged as a critical and urgent health burden during the current global
pandemic. Among multiple genetic causes, melanocortin receptor‐4 (MC4R), involved in …

Targeting BDNF modulation by plant glycosides as a novel therapeutic strategy in the treatment of depression

H Khan, S Amin, S Patel - Life sciences, 2018 - Elsevier
Current therapies in clinical practice face strong criticism regarding their efficacy, and side
effects, which forced the neuro-researchers to discover novel agents with different …

Hypothalamic TrkB. FL overexpression improves metabolic outcomes in the BTBR mouse model of autism

JM Anderson, AA Boardman, R Bates, X Zou, W Huang… - Plos one, 2023 - journals.plos.org
BTBR T+ Itpr3tf/J (BTBR) mice are used as a model of autism spectrum disorder (ASD),
displaying similar behavioral and physiological deficits observed in patients with ASD. Our …

[HTML][HTML] Exploring the Interplay of Genetics and Nutrition in the Rising Epidemic of Obesity and Metabolic Diseases

S Górczyńska-Kosiorz, M Kosiorz… - Nutrients, 2024 - mdpi.com
Background: Obesity has become a significant global health issue. This multifaceted
condition is influenced by genetic, environmental, and lifestyle factors, significantly …