Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …

The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …

Maintenance of a constant cell volume in response to extracellular or intracellular osmotic
changes is critical for cellular homeostasis. Activation of a ubiquitous volume-regulated …

Abstract Pannexin 1 (PANX1) is an ATP-permeable channel with critical roles in a variety of
physiological functions such as blood pressure regulation, apoptotic cell clearance and …

Membrane ion channels are essential for cell proliferation and appear to have a role in the
development of cancer. This has initially been demonstrated for potassium channels and is …

A fundamental property of animal cells is the ability to regulate their own cell volume. Even
under hypotonic stress imposed by either decreased extracellular or increased intracellular …

It is commonly accepted that cells require K+ channels to proliferate. The role (s) of K+
channels in the process is, however, poorly understood. Cloning of K+ channel genes …

Cell proliferation and apoptosis are paralleled by altered regulation of ion channels that play
an active part in the signaling of those fundamental cellular mechanisms. Cell proliferation …

The volume-regulated anion channel (VRAC), also known as the volume-sensitive
outwardly rectifying (VSOR) anion channel or the volume-sensitive organic osmolyte/anion …

Apoptosis is an essential process in organ development, tissue homeostasis, somatic cell
turnover, and the pathogenesis of degenerative diseases. Apoptotic cell death occurs in …