Acute myeloid leukemia: 2023 update on diagnosis, risk‐stratification, and management

S Shimony, M Stahl, RM Stone - American Journal of …, 2023 - Wiley Online Library
Disease overview Acute myeloid leukemia (AML) is a frequently fatal bone marrow stem cell
cancer characterized by unbridled proliferation of malignant marrow stem cells with …

NPM1-mutated acute myeloid leukemia: from bench to bedside

B Falini, L Brunetti, P Sportoletti… - Blood, The Journal of …, 2020 - ashpublications.org
The nucleophosmin (NPM1) gene encodes for a multifunctional protein with prominent
nucleolar localization that shuttles between nucleus and cytoplasm. NPM1 mutations …

International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data

DA Arber, A Orazi, RP Hasserjian… - Blood, The Journal …, 2022 - ashpublications.org
The classification of myeloid neoplasms and acute leukemias was last updated in 2016
within a collaboration between the World Health Organization (WHO), the Society for …

Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN

H Döhner, AH Wei, FR Appelbaum… - Blood, The Journal …, 2022 - ashpublications.org
The 2010 and 2017 editions of the European LeukemiaNet (ELN) recommendations for
diagnosis and management of acute myeloid leukemia (AML) in adults are widely …

Distinguishing AML from MDS: a fixed blast percentage may no longer be optimal

E Estey, RP Hasserjian… - Blood, The Journal of the …, 2022 - ashpublications.org
Patients with acute myeloid leukemia (AML) have conventionally received more intense
therapy than patients with myelodysplastic syndrome (MDS). Although less intense …

The International Consensus Classification of acute myeloid leukemia

OK Weinberg, A Porwit, A Orazi, RP Hasserjian… - Virchows Archiv, 2023 - Springer
Acute myeloid leukemias (AMLs) are overlapping hematological neoplasms associated with
rapid onset, progressive, and frequently chemo-resistant disease. At diagnosis, classification …

Comparison of the International Consensus and 5th WHO edition classifications of adult myelodysplastic syndromes and acute myeloid leukemia

B Falini, MP Martelli - American Journal of Hematology, 2023 - Wiley Online Library
Several editions of the World Health Organization (WHO) classifications of lympho‐
hemopoietic neoplasms in 2001, 2008, and 2016 served as the international standard for …

Clonal hematopoiesis and measurable residual disease assessment in acute myeloid leukemia

RP Hasserjian, DP Steensma… - Blood, The Journal …, 2020 - ashpublications.org
Current objectives regarding treatment of acute myeloid leukemia (AML) include achieving
complete remission (CR) by clinicopathological criteria followed by interrogation for the …

Comparison of the revised 4th (2016) and 5th (2022) editions of the World Health Organization classification of myelodysplastic neoplasms

Y Zhang, J Wu, T Qin, Z Xu, S Qu, L Pan, B Li, H Wang… - Leukemia, 2022 - nature.com
We used data from 852 consecutive subjects with myelodysplastic neoplasms (MDS)
diagnosed according to the 2016 (revised 4th) World Health Organization (WHO) criteria to …

How I diagnose and treat NPM1-mutated AML

B Falini, L Brunetti, MP Martelli - Blood, The Journal of the …, 2021 - ashpublications.org
Mutations of the nucleophosmin (NPM1) gene, encoding for a nucleolar multifunctional
protein, occur in approximately one-third of adult acute myeloid leukemia (AML). NPM1 …