Recent advances on quinazoline derivatives: A potential bioactive scaffold in medicinal chemistry

R Karan, P Agarwal, M Sinha, N Mahato - ChemEngineering, 2021 - mdpi.com
This paper intended to explore and discover recent therapeutic agents in the area of
medicinal chemistry for the treatment of various diseases. Heterocyclic compounds …

Therapeutic progression of quinazolines as targeted chemotherapeutic agents

R Bansal, A Malhotra - European Journal of Medicinal Chemistry, 2021 - Elsevier
Presently cancer is a grave health issue with predominance beyond restrictions. It can affect
any organ of the body. Most of the available chemotherapeutic drugs are highly toxic, not …

Medicinal chemistry of quinazolines as anticancer agents targeting tyrosine kinases

MF Zayed - Scientia Pharmaceutica, 2023 - mdpi.com
Cancer is a large group of diseases that can affect any organ or body tissue due to the
abnormal cellular growth with the unknown reasons. Many of the existing chemotherapeutic …

Synthesis of quinazoline and quinazolinone derivatives via ligand-promoted ruthenium-catalyzed dehydrogenative and deaminative coupling reaction of 2 …

PT Kirinde Arachchige, CS Yi - Organic letters, 2019 - ACS Publications
The in situ formed ruthenium catalytic system ([Ru]/L) was found to be highly selective for the
dehydrogenative coupling reaction of 2-aminophenyl ketones with amines to form …

Medicinal chemistry of quinazolines as analgesic and anti-inflammatory agents

MF Zayed - ChemEngineering, 2022 - mdpi.com
Quinazoline is an essential scaffold, known to be linked with various biological activities.
Some of the prominent biological activities of this system are analgesic, anti-inflammatory …

Solvent-free, mechanochemically scalable synthesis of 2, 3-dihydroquinazolin-4 (1H)-one using Brønsted acid catalyst

G Yashwantrao, VP Jejurkar, R Kshatriya… - ACS Sustainable …, 2019 - ACS Publications
Although the synthesis of novel N-heterocyclic molecules is extremely demanding as well as
challenging, the involvement of toxic solvents often triggers environmental safety concerns …

Sustainable and environmental friendly energy materials

J Robinson, N Kumari, VK Srivastava… - Materials Today …, 2022 - Elsevier
Sustainable energy refers to that energy that sustains our life for a longer period of time.
Sustainable energy materials include solar cells, fuel cells, batteries, supercapacitors …

[HTML][HTML] Synthesis, characterization, docking study and biological evaluation of new chalcone, pyrazoline, and pyrimidine derivatives as potent antimalarial …

MM Alidmat, M Khairuddean, NM Norman… - Arabian Journal of …, 2021 - Elsevier
Malaria is a protozoan disease caused by a unicellular parasite named Plasmodium
(Phylum-Apicomplexa). World Health Organization has estimated roughly fifty percent of the …

Discovery of new sulfonamide-tethered 2-aryl-4-anilinoquinazolines as the first-in-class dual carbonic anhydrase and EGFR inhibitors

WM Eldehna, ZM Elsayed, A Ammara… - International Journal of …, 2024 - Elsevier
In today's medical field, there is a growing trend of exploiting a single small molecule to
target two different molecular targets concurrently. This approach is proving to be highly …

Synthesis, Structural Studies, and α-Glucosidase Inhibitory, Antidiabetic, and Antioxidant Activities of 2,3-Dihydroquinazolin-4(1H)-ones Derived from Pyrazol-4 …

A Barmak, K Niknam, G Mohebbi - ACS omega, 2019 - ACS Publications
A series of new quinazoline derivatives were designed and synthesized via a one-pot
condensation reaction between isatoic anhydride and aromatic aldehydes with anilines …