Periodontitis, a bacterium-induced inflammatory disease that is characterized by alveolar
bone loss, is highly prevalent worldwide. Elucidating the underlying mechanisms of alveolar …

Periodontitis is the sixth most common chronic inflammatory disease, destroying the tissues
supporting the teeth. There are three distinct stages in periodontitis: infection, inflammation …

Background Periodontitis often causes irrevocable destruction of tooth-supporting tissues
and eventually leads to tooth loss. Currently, stem cell-based tissue engineering has …

Destruction of the alveolar bone in the jaws can occur due to periodontitis, trauma or
following tumor resection. Common reconstructive therapy can include the use of bone …

Abstract Purpose of Review An elevated level of pro-inflammatory cytokines in inflammatory
conditions causes bone loss and disrupts vital organ function. Osteocytes comprise> 95% of …

MicroRNAs (miRNAs) have recently been recognized to play an important role in bone-
associated diseases. This study aims to explore the expression profile and biological …

Osteoporosis is a prevalent bone metabolic disease that poses a significant challenge to
global human health. Jaw osteoporosis, characterized by microstructural damage of the jaw …

Sclerostin is the protein product of the SOST gene and is known for its inhibitory effects on
bone formation. The monoclonal antibody against sclerostin has been approved as a novel …

Periodontitis is the most common chronic inflammatory disease, and a leading cause of
tooth loss. Characterized by resorption of alveolar process and destruction of periodontal …

Type 2 diabetes (T2D) is on the rise worldwide and is associated with various complications
in the oral cavity. Using an adult-onset diabetes preclinical model, we demonstrated …