Microfluidics for drug development: from synthesis to evaluation

Y Liu, L Sun, H Zhang, L Shang, Y Zhao - Chemical reviews, 2021 - ACS Publications
Drug development is a long process whose main content includes drug synthesis, drug
delivery, and drug evaluation. Compared with conventional drug development procedures …

Droplet-based microfluidics in biomedical applications

L Amirifar, M Besanjideh, R Nasiri, A Shamloo… - …, 2022 - iopscience.iop.org
Droplet-based microfluidic systems have been employed to manipulate discrete fluid
volumes with immiscible phases. Creating the fluid droplets at microscale has led to a …

A review of experimental methods for nucleation rate determination in large-volume batch and microfluidic crystallization

C Devos, T Van Gerven, S Kuhn - Crystal growth & design, 2021 - ACS Publications
Determination of the experimental nucleation rate for crystallization in solution has been
acknowledged as an important topic for a long time, as it improves the design and control of …

Recent developments in 3D printing of droplet-based microfluidics

AD Aladese, HH Jeong - BioChip Journal, 2021 - Springer
The advent of microfluidics, especially with the integration of droplet-based systems, has led
to significant innovations and outstanding applications in many fields. While this field of …

In-depth analysis of biocatalysts by microfluidics: An emerging source of data for machine learning

M Vasina, D Kovar, J Damborsky, Y Ding, T Yang… - Biotechnology …, 2023 - Elsevier
Nowadays, the vastly increasing demand for novel biotechnological products is supported
by the continuous development of biocatalytic applications that provide sustainable green …

Bridge evolution during the coalescence of immiscible droplets

H Xu, T Wang, Z Che - Journal of Colloid and Interface Science, 2022 - Elsevier
Hypothesis Droplet coalescence is a common phenomenon and plays an important role in
many applications. When two liquid droplets are brought into contact, a liquid bridge forms …

Separation and purification of biomacromolecules based on microfluidics

FA Vicente, I Plazl, SPM Ventura, P Žnidaršič-Plazl - Green chemistry, 2020 - pubs.rsc.org
Separation and purification of biomacromolecules either in biopharmaceuticals and fine
chemicals manufacturing, or in diagnostics and biological characterization, can substantially …

Numerical simulation of droplet formation in a microfluidic T-junction using a dynamic contact angle model

J Yin, S Kuhn - Chemical Engineering Science, 2022 - Elsevier
Due to the dominance of interfacial forces, microreactors are commonly applied to
multiphase processes where control over the dispersed phase volume is critical. For the …

Effect of surfactant addition and viscosity of the continuous phase on flow fields and kinetics of drop formation in a flow-focusing microfluidic device

I Kiratzis, NM Kovalchuk, MJH Simmons… - Chemical Engineering …, 2022 - Elsevier
Droplet formation in a flow focusing microfluidic device was studied for capillary numbers
between 10− 4 and 10− 1. The addition of a cationic surfactant to the dispersed phase and …

A Tutorial Review on the Methodologies and Theories Utilized to Handle Proteins toward Obtaining Single Protein Crystals

A Adawy - Crystal Growth & Design, 2024 - ACS Publications
Proteins are functional macromolecules in living organisms including mammals and thus
human beings. They are involved in almost all biological processes, either as the main …